Utilization of Recombinant Filamentous Fungi for Protein Production.
نویسندگان
چکیده
منابع مشابه
Screening of Lovastatin Production by Filamentous Fungi
In the present study, 110 fungal strains of Persian Type Culture Collection (PTCC) including some selected strains isolated in various screening projects were tested for their potentiality to produce lovastatin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reduc-tase), the rate-limiting enzyme of cholesterol biosynthesis. The fungal strains were cultivated in a t...
متن کاملFilamentous fungi as cell factories for heterologous protein production.
Filamentous fungi have been used as sources of metabolites and enzymes for centuries. For about two decades, molecular genetic tools have enabled us to use these organisms to express extra copies of both endogenous and exogenous genes. This review of current practice reveals that molecular tools have enabled several new developments. But it has been process development that has driven the final...
متن کاملApproaches for refining heterologous protein production in filamentous fungi
Fungi combine the advantages of a microbial system such as a simple fermentability with the capability of secreting proteins that are modified according to a general eukaryotic scheme. Filamentous fungi such as Aspergillus niger efficiently secrete genuine proteins but the secretion of recombinant proteins turned out be a difficult task. Aspergillus niger is an attractive organism because of it...
متن کاملscreening of lovastatin production by filamentous fungi
in the present study, 110 fungal strains of persian type culture collection (ptcc) including some selected strains isolated in various screening projects were tested for their potentiality to produce lovastatin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coa reductase (hmg-coa reduc-tase), the rate-limiting enzyme of cholesterol biosynthesis. the fungal strains were cultivated in a t...
متن کاملProduction of L-asparaginase by filamentous fungi.
L-asparaginase production was investigated in the filamentous fungi Aspergillus tamarii and Aspergillus terreus. The fungi were cultivated in medium containing different nitrogen sources. A. terreus showed the highest L-asparaginase (activity) production level (58 U/L) when cultivated in a 2% proline medium. Both fungi presented the lowest level of L-asparaginase production in the presence of g...
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ژورنال
عنوان ژورنال: Journal of the agricultural chemical society of Japan
سال: 1993
ISSN: 0002-1407,1883-6844
DOI: 10.1271/nogeikagaku1924.67.965